Smoking, air pollution, diesel fumes are leading to an increase in incidence of lung cancer. Those working in plastic factories where benzene compounds are used are at risk of cancer of urinary bladder.
To approach the problem from a new angle, researchers in Jain's lab at Texas A&M designed a micro-device that mimics tortuous blood vessels and created a diseased microenvironment in which blood may rapidly clot underflow.
The new study shows how Type 1 interferons operate along an axis of interaction with IFNa receptors (IFNAR) to trigger a vicious cycle of inflammation. Among the effects: changes in expression of several genes associated with inflammation, glycolysis, and fatty acid production.